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KMID : 0043320120350050769
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Archives of Pharmacal Research
2012 Volume.35 No. 5 p.769 ~ p.777
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Synthesis and anticancer activity of 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones
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Phutdhawong Weerachai
Eksinitkun Gedsirin
Ruensumran Wanwikar
Taechowisan Thongchai
Phutdhawong Waya S.
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Abstract
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A series of naphthoquinones fused benzazepines, 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones, were synthesized and evaluated for their anticancer activity against four cell lines; human breast carcinoma cell line, human cervix carcinoma cell line, human hepatocellular carcinoma cell line and human keratinocyte cell line. The results showed that 5,6,8,13-tetrahydro-2,3,4,9-tetramethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4g and 5,6,8,13-tetrahydro-2,3,9-trimethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4h have significant cytotoxicity against a hepatocellular carcinoma cell line with IC50 = 3.5 μg/mL and 3.0 μg/mL, respectively.
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KEYWORD
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Naphthoquinones, Aminonaphthoquinones, Benzazepine, Anticancer agents
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